Discover, rate, and discuss biology preprints.

The paper shows that boom-and-bust growth regimes reduce selection from species interactions that affect growth rates but not from interactions that affect mortality.

PhyTaxR provides an R package for harmonizing phytoplankton taxonomic records by resolving inconsistencies and retaining uncertainty through automated and semi-automated workflows.

GlioVision predicts four glioma molecular biomarkers from MRI data using a multi-modal framework, achieving high AUC scores across multiple cohorts.

The paper shows that visual experience drives metabolic changes in endothelial cells by switching lactate and glucose transporters, essential for vascular and BBB maturation.

This study quantifies spatial asymmetry in zebrafish pectoral fin regeneration, revealing differential gene expression and signaling dynamics between anterior and posterior regions.

This study validates engineered hyper-stable human serum albumin variants for their structural integrity and functional adaptability in biotechnological applications.

This study investigates how aging and Zmpste24 deficiency affect lung progenitor cells and their fibroblast niche, showing increased susceptibility to stress and impaired regeneration.

Thyra converts Mass Spectrometry Imaging data into the SpatialData format to improve interoperability and enable multi-modal spatial analysis.

This study identifies SLC25A32 as a critical mitochondrial folate transporter that becomes essential in serine/glycine-starved triple-negative breast cancer, making it a potential therapeutic target.

This study examines how crude botanical extracts and rhizosphere soils from five plants affect soil respiration and β-glucosidase activity over 5 weeks, showing treatment-specific effects.

This study characterizes liquid-state surface fermentation (LSSF) for producing pure mycelium materials, identifying factors affecting biomass accumulation and glucose consumption.

This study shows that zebrafish larvae rely on zygotic gadusol synthesis in epidermal mucus for UVB protection after maternal gadusol depletion.

The paper identifies a minimal central pattern generator circuit for fly walking using connectome simulations and experimental validation.

The paper identifies H3K36 methylation as critical for maintaining transcriptome fidelity in metazoans by suppressing aberrant initiation in heterochromatin.

This study shows that targeting the TGFβ pathway improves CAR T cell efficacy in glioblastoma by enhancing antitumor activity and modulating the tumor microenvironment.

This paper introduces a scalable method for estimating effective connectivity in fMRI data, showing it matches advanced DCM results and outperforms functional connectivity for connectome fingerprinting.

The paper develops a computational model to predict therapeutic benefits of reducing somatic instability in Huntington's disease and validates it with preclinical experiments.

This study derives the growth rate, establishment probability, and total establishment rate of chromosomal inversions along environmental gradients using analytical theory and stochastic simulations.

This paper computationally designs light-responsive proteins that undergo conformational changes upon light activation, enabling precise control of biological functions.

This study tracks the temporal changes in the tumor microenvironment after nanobody-based CAR-T therapy, revealing dynamic gene expression shifts and identifying potential therapeutic targets.