Discover, rate, and discuss biology papers.

The paper identifies methylation changes associated with dysplasia and cancer progression in Barrett's esophagus using whole-genome methylation profiles.

This study evaluates probe registration accuracy in newborn fNIRS and HD-DOT, showing significant cap misalignment affecting spatial accuracy of functional images.

This study assesses genetic diversity and population structure of Ethiopian taro using SSR markers, finding low diversity at individual loci but high multilocus genotypic diversity and weak genetic differentiation among populations.

This study develops a non-invasive method using quantum dots to assess liver sinusoidal endothelial cell scavenger function in MASH, showing reduced retention correlates with disease progression.

The paper investigates oil biodegradation and marine oil snow formation in Arctic seawater microcosms at 4°C, finding that Pseudomonas and Pseudoalteromonas dominate oil degradation, and UV weathering significantly affects PAHs.

This study builds a 3D mathematical model of adipose tissue showing complex architectures emerge from simple mechanical rules, suggesting mechanical forces drive tissue structure more than genetic programs.

This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.

This paper reviews PSI photoinhibition in cucumber under chilling temperatures and fluctuating light, comparing causes, consequences, and protective mechanisms.

This study compares and validates two BIDS Apps, PETPrep and PICNIC, against in-house software for preprocessing UCB-J PET data, finding high consistency but region-dependent bias.

This paper introduces a framework to score and stratify MeSH co-occurrence networks for systematic literature reviews, improving the identification of relevant biological concepts.

The paper defines an RNA-centric landscape of human cell cycle control by profiling various RNA features and identifies key RNA elements involved in cell cycle regulation.

This paper develops a multimodal deep-learning model for breast cancer biomarker classification and evaluates its performance across cohorts, finding high discrimination but limited incremental value over a simpler transcript-based model.

The paper develops a method to link genes to metabolism by analyzing commonality in metabolite features associated with mQTLs, demonstrating its effectiveness through three case studies.

This study evaluates 18 cucumber genotypes across two seasons for multiple traits to identify high-performing varieties with stable multi-trait performance.

The paper models tumor volume and ctDNA dynamics in HPV-associated anal cancer to predict immunotherapy response using patient-specific parameters.

The paper presents a curated dataset of 1,413 LNP cytotoxicity measurements to examine structure-activity relationships and develop computational models of lipid nanoparticle cytotoxicity.

The paper investigates how the Spiral-Pincer scaffold regulates ATM kinase activation by oxidative stress, showing it restricts access to an oxidation-competent conformation.

This study compares the genotoxic effects of BrdU and EdU in trypanosomatids, finding EdU more genotoxic and revealing species-specific responses to DNA damage.

FastaGuard is a FASTA preflight QC tool that detects structural issues in assemblies and stops pipelines before expensive analysis, with high accuracy in identifying faults.

irAEGIS predicts immune-related adverse events from pre-treatment scRNA-seq data using a pathway-guided interpretable model, outperforming existing methods and identifying biologically relevant immune programs.