Discover, rate, and discuss biology preprints.

GSET retrieves dynamic gene signals to improve mechanistic GRN inference by identifying bridge genes involved in cell-state transitions.

This study identifies distinct peripheral elements in senataxin that mediate R-loop unwinding and RNA polymerase II regulation through structural and biochemical analyses.

This paper introduces a compact three-way junction oligonucleotide probe for multiscale RNA and protein imaging, enhancing detection while preserving nanoscale resolution and enabling large-field tissue analysis.

This study shows HER3 drives glycolysis in liver metastases of CRC and PDAC, and HER3 inhibition increases OXPHOS dependency, which can be targeted with combined therapy.

This paper introduces a geometric framework for analyzing local field potentials (LFPs) by modeling their dynamics as low-dimensional K-tori and validates it across neural datasets.

This study investigates serial dependence by showing that previous judgments influence subsequent ones through the action used to express them, not just the stimulus or decision.

The paper investigates how competition within and between groups affects cooperation in stigmergic systems using the Stigmer Game with human participants under different payment rules.

This study investigates microbial responses to oil spills in Arctic conditions by simulating oil degradation and marine oil snow formation in microcosms at 4°C.

This study shows that Polycomb-marked promoter methylation gains in aging and cancer occur independently of replication and are driven by age-related epigenetic drift rather than oncogenic signaling.

The paper investigates the state-dependent coupling between oscillatory and aperiodic neural activity using intracranial recordings and a dynamical model, finding that local inhibitory feedback drives this coupling.

This study evaluates a mucosal vaccine combining ACP and diABZI, showing enhanced TH1/TH17 responses and serum bactericidal activity against Neisseria gonorrhoeae.

The paper shows Purkinje cells in the cerebellum encode forward and inverse models for saccades in opposite directions, based on their projection targets.

The paper examines ancestry patterns and temperature effects in a Culex pipiens hybrid zone, finding urbanization increases molestus ancestry while temperature influences specific loci.

This study analyzes the tryptophan system in E. coli to show how multiple feedback loops enable rapid response and noise mitigation.

This study provides the first comprehensive survey of macroparasite communities in West African mangroves, identifies new species and host records, and establishes a baseline for future ecological monitoring.

This study shows that unfamiliar conspecifics increase freezing and shift movement towards immobility in zebrafish, particularly in males, and elevate cortisol levels overall.

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

This study shows that aging increases spinal noradrenergic activity, leading to motor neuron hyperexcitability and sarcopenia, which can be reversed by suppressing noradrenergic signaling.

The paper identifies a self-renewing lymphoid-biased HSC subset in mice that maintains lymphopoiesis during aging and may serve as a backup source for immune function.

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.