Discover, rate, and discuss biology preprints.

The paper evaluates amino acid compositional indices for detecting cold adaptation in marine Archaea and finds no evidence of cold adaptation but identifies proteomic signatures linked to sponge host adaptation.

The paper reanalyzes RNA-seq data from neuronal nuclei to identify gene expression changes associated with nuclear TDP-43 loss in FTD and ALS, finding STMN2 depletion and other transcriptomic variations.

The paper identifies widespread readthrough transcription in human cells and shows that depletion of specific factors increases its extent.

This study investigates how norepinephrine and dopamine contribute to strategic decision-making and reward learning in mice, finding distinct roles for each in tracking immediate rewards and longer-timescale strategies.

The paper models cell identity stability using a Markov framework, showing how mixing, competence, and commitment influence transition rates and proposes experiments to test these mechanisms.

This study shows that cGAS integrates TLR signaling in platelets to drive thromboinflammation by sensing mitochondrial DNA.

This paper develops a pneumatic-controlled stop-flow lithography platform to fabricate size-tunable anisotropic multilayered microparticles by regulating flow resistance and minimizing hydraulic compliance.

The paper shows maternal memory T cells protect offspring from respiratory viral infection through IL-10-mediated suppression of inflammation, independent of antibodies or offspring T cells.

The paper shows that sensory neurons open a multi-day cortical plasticity window aligned with immune responses, mediated by sequential activation of inhibitory and excitatory interneurons.

RELAY predicts cellular responses to perturbations by learning relational patterns from measured data, outperforming existing methods on unseen variable values and combinations.

The paper identifies tandem repeats in methanogenic archaea and their viruses, showing they contribute to genomic diversity and adaptation potential.

This study uses sedimentary ancient DNA metabarcoding to analyze Iron Age courtyard and cooking pit sites, identifying plant and animal taxa and highlighting challenges from bioturbation and root penetration.

The paper identifies methylation changes associated with dysplasia and cancer progression in Barrett's esophagus using whole-genome methylation profiles.

This study evaluates probe registration accuracy in newborn fNIRS and HD-DOT, showing significant cap misalignment affecting spatial accuracy of functional images.

This study assesses genetic diversity and population structure of Ethiopian taro using SSR markers, finding low diversity at individual loci but high multilocus genotypic diversity and weak genetic differentiation among populations.

This study develops a non-invasive method using quantum dots to assess liver sinusoidal endothelial cell scavenger function in MASH, showing reduced retention correlates with disease progression.

The paper investigates oil biodegradation and marine oil snow formation in Arctic seawater microcosms at 4°C, finding that Pseudomonas and Pseudoalteromonas dominate oil degradation, and UV weathering significantly affects PAHs.

This study builds a 3D mathematical model of adipose tissue showing complex architectures emerge from simple mechanical rules, suggesting mechanical forces drive tissue structure more than genetic programs.

This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.

This paper reviews PSI photoinhibition in cucumber under chilling temperatures and fluctuating light, comparing causes, consequences, and protective mechanisms.