Discover, rate, and discuss biology preprints.

Path knockout identifies dominant multi-synaptic pathways in connectomes by quantifying the impact of neuron removal on connection strength, outperforming existing methods in Drosophila circuits.

PhenoMe provides an open-source framework for analyzing microscopy images using foundation model-derived embeddings and experimental metadata to enable phenotyping and data exploration.

The paper uses 3D super-resolution tracking to show that Bacteroidota gliding involves multiple open filament tracks, challenging the single closed loop model.

The paper introduces a training-free method for particle picking and centering in cryo-EM by using a radial kernel convolution, achieving comparable reconstruction resolutions to reference-based methods.

This study shows that myelin affects hippocampal network function by shaping extracellular space, not only by insulating axons, with demyelination altering diffusion, flow, and synaptic transmission.

REGA-perturb resolves gene regulatory paths from genetic perturbations using reference epigenomes and RNA measurements, outperforming existing methods in identifying TF-target relationships and predicting regulatory changes.

This study identifies genetic variants in FGF5 and CELSR1 associated with long and rough coat phenotypes in guinea pigs, revealing distinct molecular mechanisms.

This paper introduces PGL, a Bayesian regression method for microbiome feature selection that uses phylogenetic trees to improve detection of exposure-associated ASVs.

This study develops an assay in larval zebrafish to investigate visual desensitization and its role in synaptic plasticity by measuring escape responses to varying visual stimuli.

This study isolates and characterizes W. globosa-derived nanovesicles, demonstrating their neuroprotective effects against methylglyoxal-induced oxidative stress in vitro.

This study identifies a respiratory microdomain in Toxoplasma gondii that links ubiquinone biosynthesis to succinate dehydrogenase, revealing a unique mitochondrial organization lacking complex I.

This study shows that during nutrient starvation, chromatin accessibility decreases genome-wide, but RNA abundance increases selectively in stress-adaptive genes, indicating limited predictive power of ATAC-seq for transcript abundance.

The paper presents a multimodal dataset from a 40-hour forced-desynchrony protocol to study circadian rhythms and their effects on physiology, ocular function, and behavior.

GSET retrieves dynamic gene signals to improve mechanistic GRN inference by identifying bridge genes involved in cell-state transitions.

This study identifies distinct peripheral elements in senataxin that mediate R-loop unwinding and RNA polymerase II regulation through structural and biochemical analyses.

This paper introduces a compact three-way junction oligonucleotide probe for multiscale RNA and protein imaging, enhancing detection while preserving nanoscale resolution and enabling large-field tissue analysis.

This study shows HER3 drives glycolysis in liver metastases of CRC and PDAC, and HER3 inhibition increases OXPHOS dependency, which can be targeted with combined therapy.

This paper introduces a geometric framework for analyzing local field potentials (LFPs) by modeling their dynamics as low-dimensional K-tori and validates it across neural datasets.

This study investigates serial dependence by showing that previous judgments influence subsequent ones through the action used to express them, not just the stimulus or decision.

The paper investigates how competition within and between groups affects cooperation in stigmergic systems using the Stigmer Game with human participants under different payment rules.