FDXR Upregulation by p63/p73 is a Prognostic and Therapeutic Marker of HTLV-1-Associated Adult T Cell Leukemia/Lymphoma
Lara Gallucci, Maria Josephine, Yasunori Kogure, Alex Ap. Rosini Silva, Vincent Cantaloube-Ferrieu, Marcos Eduardo Souza Abreu, Trusha Ramteke, Phoebe Kibble, Guilherme Lucchesi D Angelo Braz, Rubens de Assis Santos Sebastiao, Luiza Amoroso Lambaz, Aijun Lin, Beth Hoare, Felipe Custodio Carvalho dos Santos, Sophie Shackley, , Iart Luca Shytaj
This study identifies FDXR upregulation as a prognostic marker and therapeutic target in HTLV-1-associated ATL, showing its link to disease severity and sensitivity to fluorouracil.
bioRxiv · Feb 25, 2026 · PreprintMicrobiology