Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis
Alexus A. Smith, Edmund L. Wong, Ronan C. Donovan, Brad Chapman, Ryan Harry, Pooyan Tirandazi, Paulina Kanigowska, Elizabeth A. Gendreau, Robert H. Dahl, Michal Jastrzebski, Jose E. Cortez, Christopher Bremner, José C. Morales Hemuda, James Dooner, Ian Graves, , Reshma P. Shetty
This paper demonstrates an LLM-driven autonomous lab that reduces the cost of cell-free protein synthesis by 40% and increases titer by 27% through iterative optimization.
bioRxiv · Feb 5, 2026 · PreprintSynthetic Biology