Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn
Olivia Davis, Jane M Brandon, Keerthana Natarajan, Lucy He, Zaki Khan, Nethra Selvakumaran, Muhammad Babar, Aisha Alfayadh, Stephanie I. Shiers, Muhammad Saad Yousuf, Erin Vines, Peter Horton, Anna M. Cervantes, Tariq Khan, Geoffrey Funk, , Theodore John Price
This study examines the anatomical changes in the human lumbar spinal dorsal horn in relation to chronic lower limb pain and finds no association with neuronal density or inhibitory neuron loss.
bioRxiv · Sep 21, 2026 · PreprintNeuroscience