Developmental BiologybioRxivPreprint
A single cell trajectory of human archetypal pluripotent stem cell differentiation to trophoblast stem cells reveals induction of endogenous BMP5/7 and GATA3 without transitioning through a naive state
Ethan Tietze, Amilton de Lima Barbosa, Bruno Henrique Silva Araújo…·Jennifer A. Erwin
This paper shows that primed human pluripotent stem cells can differentiate to trophoblast stem cells without becoming naive, using specific signaling conditions and revealing a transcriptional network involving BMP5/7 and GATA3.