Molecular BiologybioRxivPreprint
The nuclear Argonaute HRDE-1 broadly interacts with euchromatin via an RGG domain to enable transgenerational epigenetic silencing
Julie Zhouli Ni, Natasha Mason, Junjie Liu…·Joyce Naguib
This study identifies the RGG domain of HRDE-1 as essential for chromatin binding and transgenerational epigenetic silencing in C. elegans, revealing a conserved mechanism for AGO-chromatin interaction.
DOI 10.64898/2026.10.15.759339