BioinformaticsProceedings of the National Academy of SciencesPeer-reviewed
Context-Dependent Design of Induced-fit Enzymes using Deep Learning Generates Well Expressed, Thermally Stable and Active Enzymes
Lior Zimmerman, Noga Alon, Itay Levin…·Gideon D. Lapidoth
This paper designs novel enzymes with improved expression, thermal stability, and activity using deep learning methods, achieving 54% expression in E. coli and 30% higher thermal stability than templates.
20 citations