Cancer BiologybioRxivPreprint
Glucocorticoid receptor activation reorganizes Wnt/LEF1 regulatory circuitry associated with therapeutic response in B-cell acute lymphoblastic leukemia
Robert J. Mobley, Damilola Oluwalana, Gabriele Baniulyte…·Daniel Savic
This study shows that GR activation reorganizes Wnt/LEF1 regulatory circuitry in B-ALL, influencing therapeutic response and resistance through chromatin state changes and gene regulation.