Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity
Martha M. S. Sim, Molly Y. Mollica, Hammodah R. Alfar, Melissa Hollifield, Dominic W. Chung, Xiaoyun Fu, Siva Gandhapudi, Daniëlle M. Coenen, Kanakanagavalli Shravani Prakhya, Dlovan F. D Mahmood, Meenakshi Banerjee, Chi Peng, Xian Li, Alice C. Thornton, James Z. Porterfield, , Jeremy P. Wood
This paper identifies a shear-dependent interaction between Protein S and von Willebrand Factor that reduces free PS anticoagulant activity and contributes to thrombotic risk in viral infections.
bioRxiv · Feb 8, 2024Biochemistry