Cancer BiologybioRxiv
The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing
M. Ghram, G. Morris, B. Culjkovic-Kraljacic…·K. Borden
This paper shows that eIF4E elevation reprograms splicing in AML, affecting thousands of transcripts and linking to poor prognosis, independent of splice factor mutations.