Cell BiologybioRxiv
Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation
Ivana Petrovska, Elisabeth Nüske, Matthias C Munder…·Simon Alberti
The paper shows that metabolic enzymes like glutamine synthetase form filaments at low pH during starvation, leading to inactivation and storage, suggesting a general mechanism for cellular adaptation to starvation.
DOI 10.7554/elife.02409