Pharmacology & ToxicologybioRxivPreprint
Target engagement studies and kinetic live-cell degradation assays enable the systematic characterization of HDAC6 PROTACs
Maria Hanl, Felix Feller, Irina Honin…·Finn Kristian Hansen
This paper presents a NanoBRET assay to assess HDAC6 target engagement and establishes a system for kinetic live-cell degradation analysis of HDAC6 PROTACs.
DOI 10.1101/2025.03.31.646177