MicrobiologybioRxivPreprint
Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses
Martin V. Hamann, Lisa Brauckmann, Christoph Schwarz…·U. Schiefer Lange
This study shows that defective HIV-1 proviruses can reprogram CD4+ T cells by altering BACH2 and STAT5B gene expression, leading to immune evasion and persistence in ART-treated individuals.
DOI 10.1101/2025.09.22.676989