Cancer BiologyCell Death DiscoveryPeer-reviewed
DNA polymerase kappa stabilized by PTBP2 interacts with MRE11 and promotes genomic instability in leukemia cells
Shristi Lama, Bibhudev Barik, Sajitha IS…·Soumen Chakraborty
The paper shows PTBP2 stabilizes Pol{kappa} mRNA, leading to genomic instability in CML cells by interacting with MRE11 and promoting DNA damage.
DOI 10.1038/s41420-026-02951-0