Disease-associated programming of cell memory in glycogen storage disorder type 1a
Uri Sprecher, J D’Souza, Kumudesh Mishra, Noam Muchtar, Or Shalev, Alexandra Eliassaf, Anna Morshina, Alexane Cannella Miliano, Gilles Mithieux, Fabienne Rajas, S Avraham, F Castellani Moses, H Kauffman, Yehudit Bergman, Nissim Garti, , Miguel Weil
This paper shows that GSD1a patient fibroblasts retain a reversible disease phenotype in vitro, driven by epigenetic and transcriptional changes, and that a drug can reverse these effects.
bioRxiv · Feb 20, 2023 · PreprintCell Biology