Cell BiologyPLoS ONEPeer-reviewed
POI-associated LMD-3 mutation impairs B12-regulated lysosomal function and reproductive capacity in C. elegans
Yile Zhai, Tiantian Wang, Meixi Gong…·Zhe Zhang
This study shows that the LMD-3 mutation in C. elegans causes reproductive failure by disrupting lysosomal function and proteostasis, which can be reversed with vitamin B12 supplementation.
DOI 10.1371/journal.pone.0361215