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This study demonstrates that AAV-mediated LRPPRC gene replacement in mice prevents cardiac dysfunction and extends survival in a mitochondrial disease model.

This study uses microhaplotype sequencing to determine the origin of recurrent Plasmodium vivax infections in Ethiopia, showing that hypnozoite relapse is the main cause in the absence of primaquine.

The paper shows that additive gene effects underlie Mendelian inheritance and contribute to heterosis by analyzing genotypic and phenotypic data from four genes.

This study investigates how genetic diversity and multiplicity of infection in Plasmodium species affect Anopheles coluzzii infectivity in Cameroon, finding that higher diversity and mixed infections increase mosquito infectivity.

The paper shows that continuous ancestry profiles better capture genetic ancestry complexity than categorical labels, using genotyped data from 28,332 individuals.

The paper develops k-mer-based tools to measure Yq12 heterochromatin size from sequencing data without complete assemblies, revealing population-scale variation and transcription in testis.

The paper shows that genetic ancestry affects allelic expression in admixed individuals, with West African ancestry linked to more ASE-positive genes.

This study uses long-read whole genome sequencing and pangenomes to identify novel variants and pathogenic findings in neurodevelopmental disorder cases from underrepresented populations.

This paper extends Mendelian randomisation to founder-haplotype data in Diversity Outbred mice, showing founder-effect patterns improve causal inference compared to scalar coding.

The paper decomposes gene coexpression networks into cell type-specific and shared components, showing that specific networks funnel genetic risk into core disease genes.

This study identifies male-specific genome sequences for non-invasive sex identification in Nishikigoi, develops PCR markers, and establishes a field-applicable diagnostic platform.

The paper identifies host genes in C. elegans required for bacterial adherence to the gut epithelium using a genetic screen.

The paper integrates exome and transcriptome data from a schizophrenia case with low polygenic risk to identify potential variants and transcriptomic abnormalities, revealing biological alterations linked to cerebrovascular disease.

This study identifies specific mutational sequences in congenital neutropenia patients that predict leukemic transformation.

This study maps quantitative trait loci modifying glycemia in MafAS64F-driven dysglycemia using genetically diverse mice.

This study analyzes genomic changes in a 50-year dairy cattle selection experiment, finding increased inbreeding and localized genetic differentiation in the selected line.

This study identifies host factors and cellular contexts governing anellovirus persistence through genomic, transcriptomic, and functional analyses.

This study shows that Saccharomyces cerevisiae persistence in mice is polygenic with strong additive effects and minimal host-genotype interactions.

This study identifies eIF4H1 as a conserved gene regulating sociality and neuronal development in Drosophila, supporting a genetic toolkit for social traits across species.

This study identifies five novel ocular enhancers in zebrafish that regulate rax expression during eye development and shows their robustness to perturbations.