Maksim Klimiankou

This study identifies specific mutational sequences in congenital neutropenia patients that predict leukemic transformation.

This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.

This study examines laminin receptors in AML, finding that integrin α7β1 marks non-leukemic stem cells with migratory potential and correlates with poor survival.

This paper designs and characterizes agonists that tune G-CSFR activity to bias granulopoiesis over proliferation, showing improved stability and selectivity compared to native G-CSF.