Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- Developmental BiologybioRxivPreprint
Homoplastic evolution of proximal podomere patterning across Arthropoda
Benjamin C Klementz, Max Hämmerle, Ethan M Laumer…·Prashant P Sharma
The paper examines proximal podomere patterning in sea spiders and arachnids, finding homoplastic evolution of gene expression patterns that challenges assumptions about leg segment homology.
DOI 10.64898/2026.10.30.763126 - BioinformaticsbioRxivPreprint
The Almond Expression Atlas: A comprehensive multi-tissue transcriptomic resource for almond gene expression
Eva M. Lopez-Fernandez, MA Zwieniecki, A. Tixier…·Pedro Jose Martinez-Garcia
The paper presents the Almond Expression Atlas, a comprehensive transcriptomic resource integrating RNA-seq data to identify tissue-specific genes and improve gene expression analysis in almond.
DOI 10.64898/2026.10.30.763019 - EcologybioRxivPreprint
Optimal Conservation Prioritization for Waterfowl and Other Birds in Eastern Canada
Daniel Dylewsky, Matthew E. Dyson, Jame E. Paterson…·Joseph R. Bennett
The paper presents an optimized geospatial prioritization scheme for bird conservation in Eastern Canada using linear programming to maximize population coverage.
DOI 10.64898/2026.10.30.763193 - Plant BiologybioRxivPreprint
Phloem conductance from leaf to fruits in avocado during development
Maria Agullo-Samper, Cristina Ferrer-Blanco, Carlos E Gonzalez…·Juan M Losada
The paper quantifies phloem conduit geometry and carbohydrate concentrations in avocado plants during development, showing changes in phloem structure and transport efficiency.
DOI 10.64898/2026.10.31.762750 - NeurosciencebioRxivPreprint
Dissection of the contribution of bushy cell delays to sound localization in juvenile and adult Mongolian gerbils
Martijn C Sierksma, J. Gerard G. Borst
This study examines how delays in bushy cell axons contribute to sound localization in Mongolian gerbils, finding developmental changes in delay patterns and their impact on interaural time difference processing.
DOI 10.64898/2026.10.30.762924 - Cancer BiologybioRxivPreprint
Quantifying subcellular organization from localization to co-occurrence with InSpace
InSpace quantifies subcellular organization by preserving localization and molecular co-occurrence, revealing spatial programs in B and plasma cells across cancers.
DOI 10.64898/2026.10.29.762981 - Cell BiologybioRxivPreprint
Cumulus cells mediate the protective effect of the marine carotenoid fucoxanthin against postovulatory oocyte aging via NRF2 signaling
Chansik Oh, Soon-Tae Kwon, Hyuk Nam Kwon…·Sangyong Jung
This study shows that fucoxanthin protects mouse oocytes from postovulatory aging by activating NRF2 in cumulus cells, improving mitochondrial function and reducing oxidative stress.
DOI 10.64898/2026.11.01.763385 - Evolutionary BiologybioRxivPreprint
Convergent genome- and gene-level constraints shape repeated environmental adaptation in grasses
Sheng‐Kai Hsu, Aimee J Schulz, Charles O. Hale…·Edward S. Buckler
This study identifies convergent genomic and gene-level constraints in grasses adapting to extreme environments using phylogenomic data and large language models.
- BioinformaticsbioRxivPreprint
ToxINsight: An Integrated Web Platform for Sequence, Structure, and Ligand Binding Analysis of Snake Venom Toxins
Aayushi Gupta, Tukkapuram Venkata Lalith Krishna, Bipin Singh
ToxINsight provides a web platform for analyzing snake venom toxin sequences, structures, ligand interactions, and geographical distributions to aid in antivenom development.
DOI 10.64898/2026.10.27.762231 - Plant BiologybioRxivPreprint
The cell polarity landscape in Arabidopsis male and female gametophytes
Samuel Koh Wee Han, Monique van Schie, Catherine Albrecht…·Dolf Weijers
The paper identifies polar domains in Arabidopsis male and female gametophytes using conserved proteins, revealing a universal polarity system and uncovering novel polar domains.
DOI 10.64898/2026.10.30.763139 - MicrobiologybioRxivPreprint
Age Associated Shifts Toward Anaerobic Taxa and Amino Acid Degradation Potential in the Canine Oral Microbiome
Zhiyue Jiang, Madeline Shono, Aisling Archdeacon…·Matteo Pellegrini
This study examines age-related changes in the canine oral microbiome, finding increased anaerobic taxa and amino acid degradation potential with age.
DOI 10.64898/2026.10.30.763000 - Cell BiologybioRxivPreprint
Cannabidiol Impairs Glucagon Trafficking and Secretion Through the Lysosomal System in Murine αTC1-6 cells
Samuel Ugulini, Daniel B Hardy, Savita Dhanvantari
This study shows that CBD reduces glucagon secretion in mouse αTC1-6 cells by altering lysosomal trafficking and secretion pathways.
DOI 10.64898/2026.10.30.762933 - MicrobiologybioRxivPreprint
Cross-regulatory sRNA networks shape adaptive stress responses in Staphylococcus aureus: RsaC and RsaOI regulate galactose metabolism and cell wall homeostasis
Hugo ROBIN, Maeliss GERMAIN, Chloe SILARD…·Astrid Rouillon
This study identifies regulatory interactions between sRNAs and transcription factors in S. aureus, showing their roles in stress responses and virulence.
DOI 10.64898/2026.10.30.763024 - PhysiologybioRxivPreprint
No Effect of Exercise Timing on Daily Glycaemia Despite Shifts in Acute Glucose Dynamics in Participants with Normal Glucose Tolerance: A Randomised Crossover Trial
Lara T Dasar, Matthew Hamilton, Daria Borisova…·Brendan M Gabriel
This study shows that exercise timing does not affect overall daily glucose exposure but alters acute glucose dynamics and variability.
DOI 10.64898/2026.10.30.763114 - BiochemistrybioRxivPreprint
Structure of influenza D virus NS1 reveals a novel Zn-binding site and ssRNA-binding activity
Kai Ye, Minhui Guan, Andrew S Kim…·Yizhi J Tao
This study determines the structure of influenza D virus NS1, identifies a novel Zn-binding site and RNA-binding activity in its CTD, and shows their importance for viral replication.
DOI 10.64898/2026.10.29.760789 - MicrobiologybioRxivPreprint
NAD Metabolism Drives CTCF-Cohesin Chromatin Regulation in EBV-Transformed B-Cells
Davide Maestri, Rachel Sklutuis, Lisa Beatrice Caruso…·Italo Tempera
This study shows that NAD metabolism supports CTCF-cohesin chromatin regulation in EBV-transformed B-cells and identifies NAMPT inhibition as a potential therapeutic strategy.
DOI 10.64898/2026.11.01.763250 - BioengineeringbioRxivPreprint
Investigating the therapeutic potential of soluble TREM2 interactions with Transgelin-2 in Alzheimer's disease
David Saeb, Emma E Lietzke, Evan A Wood…·Kayla G Sprenger
This study identifies the structural basis of sTREM2-TG2 interaction in Alzheimer's disease and develops improved peptide modulators based on these findings.
DOI 10.64898/2026.10.30.763206 - Cell BiologybioRxivPreprint
Modeling ATN1 mutations in human iPSCs reveals early developmental roles of atrophin-1
Emilia Kozlowska, Natalia Ziojla, Bartosz Nowak…·Agnieszka Fiszer
This study generates an isogenic iPSC panel to investigate ATN1's role in human development and disease, revealing proliferation deficits and toxic gain-of-function effects in mutant ATN1 lines.
DOI 10.64898/2026.10.30.760413 - NeurosciencebioRxivPreprint
Nucleus accumbens acetylcholine dips track reward value and temporal costs to shape delay discounting
Julianna Cavallaro, Dustin R Zuelke, Czarina M Maysonet…·Eduardo F Gallo
This study shows that nucleus accumbens acetylcholine dips track reward value and delay, influencing adaptive choice in mice during delay discounting tasks.
DOI 10.64898/2026.10.30.760841