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CD90 identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance

The paper identifies CD90 as a marker distinguishing two muscle stem cell subpopulations with different activation kinetics and quiescence maintenance mechanisms in mice and humans.

Understanding range-wide immune gene variation in an endangered big cat (Panthera tigris)

This study assesses non-MHC immune gene diversity in tigers using whole-genome data, finding higher variation at immune receptor genes and signs of balancing selection on Toll-like receptors.

Quantifying microbial fitness in high-throughput experiments

This study examines how different fitness statistics in high-throughput microbial experiments affect interpretations of mutant fitness and evolutionary dynamics.

The cyclin-G associated kinase (GAK) is a novel mitotic kinase and therapeutic target in diffuse large B-cell lymphoma

This paper identifies GAK as a novel mitotic kinase and therapeutic target in DLBCL, showing that GAK inhibition causes mitotic defects and that existing drugs can be repurposed for its targeting.

Integrating pangenome and imputation framework reveals structural variants affecting stature and milk composition traits in French dairy cattle

The paper integrates long-read, short-read, and SNP data using a pangenome and imputation framework to identify structural variants associated with stature and milk traits in dairy cattle.

Born on Mars: Multigenerational phenotypic change in Caenorhabditis elegans under Martian analog gravity and hypomagnetic fields

This study examines transgenerational effects of Martian analog gravity and hypomagnetic fields on C. elegans, finding progressive impairments and increased phenotypic variability across generations.

Fatty acid desaturation guides cellular decisions between ferroptosis and cellular senescence

The paper shows that fatty acid desaturation, specifically DGLA, influences cellular decisions between ferroptosis and senescence, with implications for aging and obesity.

Governing the decline: clam fisheries and the challenges of decentralized management across the western Mediterranean and Gulf of Cadiz (Spain).

This study compares ecological and governance trends in Spanish clam fisheries, finding that adaptive management in Andalusia led to more resilient outcomes compared to fragmented governance in the northwest Mediterranean.

Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances

This paper uses pesticide toxicity data to identify substances that improve survival and healthspan by affecting mitochondrial bioenergetics.

Pseudomonas aeruginosa MucP contributes to RNA phage resistance by targeting phage lysis

This study shows that MucP, a protease in Pseudomonas aeruginosa, reduces RNA phage PP7 lysis by targeting its lysis protein's transmembrane helix, providing resistance against phage-induced cell lysis.

Anti-HIV-1 B cell antigen receptor signaling and structure

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

Farm exposure is associated with human breast milk immune profile and microbiome

The paper compares immune profiles and microbiomes of breast milk from mothers with different farm exposures to identify associations with immune development and atopic disease.

Visualization and Morphological Analysis of Individual Oligodendrocytes in the Mouse White Matter

The paper describes methods to visualize and analyze the morphology of individual oligodendrocytes in mouse white matter using genetic labeling and immunostaining techniques.

Full Scan enhanced Dynamic Range MS improves metabolite coverage and cancer cell-line discrimination in untargeted metabolomics

This paper introduces Full Scan enhanced Dynamic Range MS to improve metabolite detection in untargeted metabolomics, increasing feature detection and enabling better discrimination between cancer cell lines.

Beyond Imbalance: An Elasticity Framework for the Distance-averaged Force-Velocity Relationship in Vertical Jump

This paper develops an elasticity framework to quantify how force-velocity relationship variables affect jump height and provides metrics for training prescription.

Specification of bone marrow sinusoids requires TIE2-mediated positive feedback involving COUPTFII and VEGFR3

This study identifies TIE2-mediated positive feedback involving COUPTFII and VEGFR3 as essential for bone marrow sinusoid specification.

A responsivity theory of call timing patterns in bat echolocation

Decomposing bat echolocation interpulse intervals into acoustic acquisition and proportional behavioural intervals explains hyperbolic call-rate trajectories, terminal buzz update budgets, buzz readiness, and multi-target sonar strobe groups.

The epidermal stem cell-supporting matricellular protein fibulin 7 modulates skin inflammatory response in a psoriasis model

This study shows fibulin 7 protects against skin inflammation by modulating IL-17A signaling in a psoriasis model.

The metabolic resistance blueprint: Genomic dissection of DDT resistance in historical kdr-free East African Anopheles gambiae

This paper identifies genomic loci and mutations associated with DDT metabolic resistance in Anopheles gambiae using bulk segregant analysis and confirms their selection in natural populations.

Advancing global DNA-referencing of bushmeat in African tropical forests: a tool for identifying trade hotspots and dynamics in western and central Africa

The paper develops a DNA-typing reference database to trace bushmeat trade in Africa, identifying species and trade hotspots with high accuracy.