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This study identifies a multipotent secretory cell population in mouse distal airways that contributes to both airway and alveolar regeneration after injury.

This study investigates whether FIT samples can reveal a microbial signature of sessile serrated lesions, finding no significant differences in community structure but suggesting potential functional differences.

The paper introduces SMAUG, a semi-automated tool for analyzing actin filament dynamics from TIRF microscopy images, reducing analysis time while maintaining accuracy.

The paper identifies subgroup-specific isoform usage and switching in SLE patients with distinct autoantibody profiles, highlighting their functional relevance in autoimmune pathogenesis.

This study shows how reinforcement learning modifies specific dendritic activity through synaptic plasticity, leading to the formation of task-relevant synaptic ensembles.

scCont is an unsupervised contrastive learning framework that extracts interpretable functional transition units from scRNA-seq data, outperforming baseline methods in capturing biologically meaningful dynamics.

The paper investigates olfactory receptor repertoire variation in New World monkeys, finding that lineage-specific histories, not shared ecological drivers, shape olfactory evolution.

This study examines urban weed response to elevated salt levels through garden experiments, finding some support for salt tolerance adaptation but highlighting environmental heterogeneity and plant variability.

This study uses sparse eGFP labeling to compare astrocyte morphology across brain regions and sexes in mice, finding sex-dependent and region-specific changes after early-life stress.

GIBD detects IBD segments in pangenome graphs and annotates them with structural variants, outperforming existing methods in accuracy and speed.

This study evaluates AAV9-mediated SLC9A6 gene replacement in shaker rats, showing early treatment preserves cerebellar structure and motor function, while later treatment has diminishing effects.

CytoBridge reconstructs continuous virtual cell dynamics from sparse spatial transcriptomic data across development, regeneration, and neurodegeneration.

This study uses genomic analysis to reclassify the Streptococcus anginosus group into four taxa, revealing diversity and lineage-associated traits linked to invasive disease.

This study establishes a scalable ex vivo platform using frozen human skin biopsies to study inflammatory responses in skin structural cells.

The paper shows that Pseudomonas fluorescens protects Chlamydomonas reinhardtii from Pseudomonas protegens by inactivating its toxin protegencin in a tripartite microbial interaction.

JANUS discovers somatic structural variants in cancer genomes using a pangenome graph approach, achieving high accuracy and efficiency compared to traditional methods.

This study examines proteomic changes in Geodermatophilus obscurus G20 under UV stress, showing distinct responses in acute and recovery phases.

The paper examines the balance between apoptosis and arrest-associated transcriptional programs in untreated PDAC, finding a consistent bias toward arrest programs.

The paper shows that during infection, Botrytis cinerea reallocates its transcriptome, altering synonymous codon demand across different host systems.

The paper describes a rare observation of a nocturnal arboreal kinkajou being followed by a puma in a rainforest canopy.