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Time-course single-cell RNA-seq of NR5A1-GFP+ mouse XY gonad cells points to one multipotent somatic progenitor pool that yields Sertoli cells and, progressively, steroidogenic Leydig precursors.

Nanopore-only sequencing of GM12878 across 39 MinION flowcells (91.2 Gb) yielded an assembly with NG50 ∼3 Mb; adding 5× ultra-long reads raised NG50 to 6.4 Mbp.

Fine-tuned ImageNet ResNets beat Inception models on tissue micro-array and BreaKHis slides, reaching 99.8% across four tumour tissues and 96.4% across four malignant sub-types.

Reanalysis of three human embryo scRNA-seq datasets resolves cell-type ambiguities, defines epiblast and primitive endoderm prototypes, and identifies t2iLGö and 5i/L/A naïve stem cells as epiblast-like.

BUSCO v3 quantifies genome, gene set and transcriptome completeness via near-universal single-copy orthologs and repurposes them for gene predictor training, reference selection, and phylogenomic marker discovery.

Open-source QuPath combines tile-based whole slide viewing, object hierarchies and trainable classifiers; it automated CD3, CD8, p53, PD-L1 and stromal scoring that stratified colon cancer survival.

ComBat, an empirical Bayes location-and-scale model from genomics, removes additive and multiplicative scanner effects from regional cortical thickness across 11 scanners while preserving age associations.

RNA-seq and 3′ end counting over 18 zebrafish stages (1-cell to day 5) profile 23,642 genes; over 100 chromosome 4 zinc finger genes peak at zygotic genome activation.

In suspended human keratinocytes, five induced phosphatases dampen ERK to drive differentiation commitment, opposed by DUSP10, in a time-rewired network that renders commitment an unstable switch.

A crude country-level model projects over 60 million patients will have healthcare-funded genome sequencing by 2025; the GA4GH authors separately give eight arguments for virtual cohorts of 100 million+.

A collection of over 18,000 Drosophila driver lines (GAL4, LexA, split-GAL4) was built, with adult male brain expression imaged for over 14,000 lines.

On LIDC-IDRI, gradient boosting on 3D dual path network features reaches 90.44% accuracy on annotated nodules; with a 3D Faster R-CNN detector, patient-level accuracy is 81.41%, 99% of doctors' average.

BITE, an R package, wraps SNP quality control, Kolmogorov-Smirnov-checked representative subsampling, color-consistent ancestry plots, and bootstrap-supported TreeMix gene-flow trees for biodiversity genomics.

Monocle 2 learns branched single-cell trajectories without supervision via reversed graph embedding, revealing a non-fusing myoblast outcome and knockout myeloid cells diverted onto opposite fate branches.

dRep groups genomes with fast Mash distances, then accurate ANI, de-replicating 1,125 infant gut genomes in 92 CPU hours versus 2,784 for naive gANI.

Quality-controlled genotypes for 488,377 UK Biobank participants at 805,426 markers, imputed to ~96 million variants, plus ancestry PCs, kinship (30.3% have close relatives enrolled) and HLA calls.

Suite2p processes two-photon calcium movies faster than real time on desktop workstations, roughly doubling curated cell yield over CNMF and recovering 13,451 neurons in one session.

Read pairs that fail kallisto pseudoalignment because of conflicting matches are filtered by pizzly to call, assemble and quantify gene fusions from raw RNA-seq in minutes rather than hours.

A dense multi-electrode array spike sorter that triages collisions, clusters clean waveforms with a coreset Dirichlet process mixture, then deconvolves, giving more stable clusters and faster template learning than KiloSort.

Sub-genic missense depletion in ExAC anchors MPC, a deleteriousness score; de novo missense variants with MPC ≥ 2 occur in neurodevelopmental cases at 5.79 times the control rate.