Discover, rate, and discuss biology preprints.

The paper investigates how bat cells respond to Toxoplasma gondii infection, finding delayed host transcriptional activation despite efficient parasite replication.

This study tests sublingual buprenorphine/naloxone film in rats, showing feasible dosing with clinically relevant plasma exposure and no significant liver toxicity.

The paper develops a deep learning-enhanced fragment ion indexing method to reduce memory usage in tandem mass spectrometry searches while maintaining search accuracy and speed.

This study shows that real-time visual cues during suboptimal arousal-attentional states improve item memory but not source memory during retrieval.

This study characterizes the in vitro metabolism and in vivo pharmacokinetics of ent-verticilide, showing rapid NADPH-dependent depletion and CYP3A-mediated metabolism with low oral bioavailability.

The paper maps bacterial bile amidation by analyzing BSH transaminase activities and identifying BBAs in human samples.

The paper describes a new Alternaria species isolated from invasive garlic mustard, highlighting its broad host range and potential agricultural biosecurity risks.

The paper analyzes the C. elegans connectome to show recurrence and convergence patterns in neural signaling, revealing structural substrates for non-feed-forward signaling.

This study investigates factors associated with Game Transfer Phenomena (GTP) and finds that creativity and positive schizotypy are linked to GTP frequency, while perceptual priming is not.

The paper develops SiMPLeSENSE, a simulated-IMU pipeline that estimates knee joint contact forces using motion capture and EMG, validated against in vivo measurements with high accuracy.

This paper shows PCBP1 interacts with utrophin-A mRNA, represses its expression by promoting nuclear retention, and identifies the KH1 domain as critical for this interaction in mouse myoblasts.

This study shows that transcranial alternating current stimulation (tACS) can reverse cognitive and cellular deficits caused by adolescent alcohol exposure in rats.

This paper uses morphology-based foundation-model embeddings to define a morphologic state space across breast lesion categories, revealing a pathobiological continuum associated with tumor development.

The paper describes DarHTG, a bacterial phage defense system that ADP-ribosylates double-stranded DNA using a helicase co-toxin, and identifies two subclasses with distinct target bases.

This study investigates how uncertainty is transformed during multimodal comprehension through a hierarchical framework tested in gesture-speech experiments.

DoAggregate performs rare-variant aggregation tests across genes, pathways, and GO terms, providing detailed cohort-level results and visualizations.