Pharmacology & ToxicologybioRxivPreprint
Characterizing the Metabolic Fate and Pharmacokinetics of the RyR2 Inhibitor ent-Verticilide
Tri Q Do, Rachel D Crouch, Madelaine P Thorpe…·Wendell S Akers
This study characterizes the in vitro metabolism and in vivo pharmacokinetics of ent-verticilide, showing rapid NADPH-dependent depletion and CYP3A-mediated metabolism with low oral bioavailability.