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This study identifies Yap as a critical regulator of tracheoesophageal separation during foregut development, showing that its loss causes a distinct Type A EA/TEF phenotype.

The paper investigates how oligodendrocytes contribute to the formation of α-synuclein filaments in multiple system atrophy by comparing seeded aggregation in different cell types.

WhaleSonic provides a raw acoustic dataset of cetacean vocalizations in Northern Norway, supporting multichannel algorithms for source separation and communication analysis.

This study identifies the TAN gene as the causal factor for astringency loss in PCNA persimmon cultivars through haplotype-resolved forward genetics and long-read sequencing.

TileScope quantifies spatial gene expression relationships beyond simple colocalization, distinguishing regional enrichment from internal covariation in glioblastoma and other tissues.

This paper introduces ipSAE, a directional scoring framework for assessing confidence in predicted biomolecular complexes, showing improved performance over existing methods in protein-ligand and protein-DNA interactions.

This study shows monounsaturated fats reduce cholesterol crystals in lipid droplets, while saturated fats promote their formation in mice with MASH.

BundleMorphometry quantifies local white matter bundle shape using nonlinear registration, revealing deformation patterns in glioma and Parkinson's disease datasets.

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

This paper develops a parameter-efficient transfer learning framework to discover antimicrobial peptides with high potency and low cytotoxicity using protein language models.

scSTEC directly annotates chromatin subcompartments from individual single-cell Hi-C matrices without imputation or cross-cell sharing, achieving results comparable to scGHOST with greater interpretability.

This study establishes a chronic motor nerve transection model in rats and characterizes distinct pathological changes in proximal and distal nerve stumps.

This study integrates and analyzes scRNA-seq data from hematopoietic stem and progenitor cells of patients with Fanconi anemia and Telomere Biology disorders, identifying distinct gene expression profiles and shared transcriptional programs.

This paper compiles a national-scale bryophyte occurrence dataset for Brazil, integrating multiple sources to enable macroecological and conservation analyses.

This study identifies RBM3 as a host factor that promotes PEDV infection by stabilizing viral RNA and upregulating the entry factor HSPA5.

This study shows that the basic segment of the AtVLN4 linker bundles actin filaments and is influenced by temperature and potassium ions.

This study determines the cryo-EM structures of Cereibacter sphaeroides ferrochelatase, revealing oligomeric states that occlude the substrate-binding site.

This study shows compost improves tomato drought resilience by enhancing water retention and modulating root gene expression through its microbial community.

This paper shows that heterogeneous spiking networks can produce fast rate-based dynamics without assuming Poisson spikes or slow dynamics.

Path knockout identifies dominant multi-synaptic pathways in connectomes by quantifying the impact of neuron removal on connection strength, outperforming existing methods in Drosophila circuits.