Andrew Hitchcock

This study determines the cryo-EM structures of Cereibacter sphaeroides ferrochelatase, revealing oligomeric states that occlude the substrate-binding site.

This study uses cryo-EM to determine the structure of the CobST cobaltochelatase motor and reveals how ATP and CobT regulate its assembly and activation for cobalt chelation.

The paper identifies PusCD1 and PusCD2 complexes in Flavobacterium johnsoniae that enable growth on phosphatidylinositol, revealing a new mechanism for phosphorus utilization in plant-associated Bacteroidota.

This paper reports a 13-subunit c-ring in the Chlamydomonas chloroplast ATP synthase, which lowers the H+/ATP cost of carbon fixation compared to the 14-subunit structure in spinach.

The paper determines the structure of the ChlG2HliD2 complex using cryo-EM to elucidate chlorophyll synthesis and photoprotection mechanisms.

This paper investigates how varying carotenoid conjugation lengths in bacterial LH2 complexes affect exciton dynamics and singlet-triplet annihilation, revealing that lower carotenoid triplet energy improves BChl triplet quenching.

This study shows that tethering FNR to PSI in Chlamydomonas reinhardtii promotes CET over LET, reducing CO2 fixation.

The paper identifies a conserved gene cluster in Flavobacterium that enables efficient xyloglucan utilization, revealing its role in plant-associated bacterial nutrient acquisition.

This study identifies sulfoquinovosyl diacylglycerol (SQDG) as essential for dimerization of the RC-LH1 complex in Rhodobacter sphaeroides, but not for its monomeric function.

This paper introduces RFAA and RFdiffusionAA, models that can predict and design complex biomolecular assemblies including proteins, nucleic acids, small molecules, and covalent modifications.

The paper demonstrates a combinatorial metabolic engineering approach in cyanobacteria that achieves stable overproduction of lycopene from CO2 without iterative optimization.

This paper introduces a rhamnose-inducible promoter system in cyanobacteria with improved properties over existing systems.