Discover, rate, and discuss biology preprints.

This study investigates microbial responses to oil spills in Arctic conditions by simulating oil degradation and marine oil snow formation in microcosms at 4°C.

This study shows that Polycomb-marked promoter methylation gains in aging and cancer occur independently of replication and are driven by age-related epigenetic drift rather than oncogenic signaling.

The paper investigates the state-dependent coupling between oscillatory and aperiodic neural activity using intracranial recordings and a dynamical model, finding that local inhibitory feedback drives this coupling.

This study evaluates a mucosal vaccine combining ACP and diABZI, showing enhanced TH1/TH17 responses and serum bactericidal activity against Neisseria gonorrhoeae.

The paper shows Purkinje cells in the cerebellum encode forward and inverse models for saccades in opposite directions, based on their projection targets.

The paper examines ancestry patterns and temperature effects in a Culex pipiens hybrid zone, finding urbanization increases molestus ancestry while temperature influences specific loci.

This study analyzes the tryptophan system in E. coli to show how multiple feedback loops enable rapid response and noise mitigation.

This study provides the first comprehensive survey of macroparasite communities in West African mangroves, identifies new species and host records, and establishes a baseline for future ecological monitoring.

This study shows that unfamiliar conspecifics increase freezing and shift movement towards immobility in zebrafish, particularly in males, and elevate cortisol levels overall.

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

This study shows that aging increases spinal noradrenergic activity, leading to motor neuron hyperexcitability and sarcopenia, which can be reversed by suppressing noradrenergic signaling.

The paper identifies a self-renewing lymphoid-biased HSC subset in mice that maintains lymphopoiesis during aging and may serve as a backup source for immune function.

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.

ARCADE improves spatial transcriptomic analysis by separating cell abundance from transcriptional state, enhancing deconvolution accuracy and interpretability in complex tissues.

The paper examines long-term biodiversity responses to human activity in coastal wetlands using sedimentary DNA and environmental data, finding context-dependent relationships between enrichment and biodiversity.

This study shows that inhibitory control during language comprehension and motor inhibition share a domain-general mechanism involving the subthalamic nucleus.

This paper develops a scalable, thermodynamically reversible stochastic operator for macromolecular dynamics, showing universal reduction laws and improved performance over existing methods.

This study shows aging causes bidirectional transcriptional changes in cardiac immune cells during LPS-induced endotoxemia, with shared mitochondrial remodeling and cell-type-specific functional shifts.

This study identifies adipocyte Kindlin-2 as a regulator of skin wound healing through an endocrine axis involving E-cadherin, β-catenin, and IGFBP2.

ssGSEA3.0 improves statistical significance assessment in ssGSEA by using feature-level bootstrap resampling, enhancing detection power while maintaining calibration across weighting schemes.