Fang Fang

Oscillatory Phase Coding Emerges in Adaptive RNNS for Flexible Working Memory

This study shows that oscillatory phase coding emerges in adaptive RNNs during sequence working memory tasks, with phase encoding serial order and amplitude encoding item identity.

Aging reshapes cardiac extravascular leukocyte transcription through bidirectional remodeling during LPS-induced endotoxemia

This study shows aging causes bidirectional transcriptional changes in cardiac immune cells during LPS-induced endotoxemia, with shared mitochondrial remodeling and cell-type-specific functional shifts.

Metagenomic and metabolomic analysis of a bryozoan-associated microbial complex from the Hanjiang River, China

This study analyzes the metagenomic and metabolomic composition of a bryozoan-associated microbial complex in the Hanjiang River, revealing its structure, functional roles, and interactions.

Enzymatic Degrading Chlorophenol Wastewater by Mixed Strains of Immobilized White Rot Fungi

This paper develops an immobilized mixed white rot fungi strain to degrade chlorophenol wastewater, achieving high 2,4-DCP degradation efficiency.

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques

This paper establishes a rhesus macaque model of glaucomatous neurodegeneration using silicone oil injection, showing RGC death, optic nerve degeneration, and functional deficits similar to human glaucoma.

Geraniol Enhances Inhibitory Inputs to Paraventricular Thalamic Nucleus and Induces Sedation in Mice

This study shows that geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice by modulating neuronal activity and GABAA receptor function.

Molecular detection of pathogens in ticks and fleas collected from companion dogs and cats in East and Southeast Asia

This study molecularly detects pathogens in ticks and fleas from companion dogs and cats in East and Southeast Asia, finding high prevalence of zoonotic vector-borne pathogens.

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

The paper analyzes single-cell RNA-seq data from human embryos to compare gene expression between males and females, identifying differences in sex chromosome activation and dosage compensation during early development.

Silicone oil-induced ocular hypertension in mouse models glaucomatous neurodegeneration and neuroprotection

This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

This paper introduces AnnoPred, a framework that uses functional annotations to improve genetic risk prediction for complex diseases, showing enhanced accuracy across multiple diseases.