Characterization of tri-culture alveolar-like organoids to study fibrotic lung diseases
Tony J. F. Guo, Yidan Meng, Seowon Kim, Tak Machiri, A Miscampbell, Kevin S.K. Lau, Clara Gibbons, Mackenzie R. Penton, Charlotte P.S. Lee, Isaac T. S. Li, Gillian C. Goobie, Andrew J. Halayko, Christopher J. Ryerson, Christopher Carlsten, Min Hyung Ryu, Emmanuel T. Osei
This study develops a 3D tri-culture alveolar organoid model to investigate fibrotic lung disease responses to TGF-β and bleomycin, revealing distinct transcriptional changes and signaling pathways.
bioRxiv · Sep 9, 2026 · PreprintCell Biology