Isolates from colonic spirochaetosis in humans show high genomic divergence and carry potential pathogenic features but are not detected by 16S amplicon sequencing using standard primers for the human microbiota
K. Thorell, L. Inganäs, A. Backhans, L. Agreus, A. Öst, M. Walker, N. J. Talley, L. Kjellström, A. Andreasson, L. Engstrand
The paper isolates and genomes Brachyspira species from colonic spirochaetosis cases, showing genetic diversity and potential pathogenic features, but finds standard 16S primers fail to detect them.
bioRxiv · Feb 8, 2019 · PreprintMicrobiology