Leader cell activity and collective invasion by an autocrine nucleotide loop through connexin-43 hemichannels and ADORA1
A. A. Khalil, O. Ilina, A. Vasaturo, J.-H. Venhuizen, M. Vullings, V. Venhuizen, A. Bilos, C. Figdor, P. N. Span, P. Friedl
The paper identifies Cx43/ADORA1 autocrine signaling as critical for leader cell activity and collective invasion in breast cancer.
bioRxiv · Dec 30, 2019Cancer Biology