Mechanical confinement and DDR1 signalling synergise to regulate collagen-induced apoptosis in rhabdomyosarcoma cells
J. Gonzalez-Molina, K. M. Kirchhof, B. Rathod, L. Moyano-Galceran, M. Calvo-Noriega, G. Kokaraki, A. Bjorkoy, M. Ehnman, J. W. Carlson, K. Lehti
This study shows that dense collagen-rich environments induce apoptosis in rhabdomyosarcoma cells via DDR1 and TRPV4 signaling, explaining their preference for low collagen microenvironments.
bioRxiv · Apr 26, 2022 · PreprintCancer Biology