Preprint: Environmentally-Friendly Workflow Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking For the Discovery of Potent Anti-Viral Leads From Plants
L.-F. Nothias, S. Boutet-Mercey, X. Cachet, E. De La Torre, L. Laboureur, J.-F. Gallard, P. Retailleau, A. Brunelle, P. C. Dorrestein, J. Costa, L. M. Bedoya, F. Roussi, P. Leyssen, J. Alcami, J. Paolini, , D. Touboul
This paper develops a supercritical fluid chromatography and tandem mass spectrometry workflow to isolate and identify antiviral compounds from plant extracts, discovering two potent antiviral diterpene esters.
bioRxiv · Feb 5, 2017Pharmacology & Toxicology