Regulation of the error-prone DNA polymerase polκ by oncogenic signaling and its contribution to drug resistance
K. Temprine, E. M. Langdon, K. Mehta, A. Clapp, R. M. White
Cancer cells under stress from oncogene or mTOR inhibition dysregulate the error-prone DNA polymerase polκ, which contributes to drug resistance in melanoma cells.
bioRxiv · May 11, 2018Cancer Biology