Harnessing Avidity: Quantifying Entropic and Energetic Effects of Linker Length and Rigidity Required for Multivalent Binding of Antibodies to HIV-1 Spikes
T. Einav, S. Yazdi, A. Coey, P. J. Bjorkman, R. Phillips
This paper models synthetic diFabs with DNA linkers to quantify how linker length and rigidity affect antibody neutralization potency against HIV-1.
bioRxiv · May 22, 2019Immunology