Isolation of Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to Fosmidomycin
G. Pines, M. C. Bassalo, E. J. Oh, A. Choudhury, A. D. Garst, R. T. Gill
The paper identifies mutations in the IspC gene of E. coli that confer resistance to fosmidomycin, a malaria drug, using CRISPR-based screening.
bioRxiv · Apr 7, 2018Microbiology