A combinatorial anticancer drug screen identifies off-target effects of epigenetic chemical probes
S. H. Barghout, M. K. Mann, Y. Yu, A. D. Schimmer, M. Schapira, C. H. Arrowsmith, D. Barsyte-Lovejoy
This study identifies epigenetic chemical probes that enhance TAK-243 cytotoxicity via off-target ABCG2 inhibition and develops a cell-based assay to measure ABCG2 inhibition.
ACS Chemical Biology · Oct 21, 2022Peer-reviewedPharmacology & Toxicology