A deep learning system can accurately classify primary and metastatic cancers based on patterns of passenger mutations
W. Jiao, G. Atwal, P. Polak, R. Karlic, E. Cuppen, A. Danyi, J. de Ridder, C. van Herpen, M. P. Lolkema, N. Steeghs, G. Getz, Q. D. Morris, L. D. Stein, PCAWG Pathology & Clinical Correlates Working Grp, ICGC/TCGA Pan-cancer Analysis of Whole Genomes Net
This paper develops a deep learning classifier using whole genome sequencing data to distinguish cancer types and identify metastatic origins.
bioRxiv · Jan 22, 2019 · PreprintCancer Biology