Single-cell immune profiling reveals the impact of antiretroviral therapy on HIV-1-induced immune dysfunction, T cell clonal expansion, and HIV-1 persistence in vivo
J. A. Collora, D. Pinto-Santini, S. Pasalar, N. Ravindra, C. Ganoza, J. Lama, R. Alfaro, J. Chiarella, S. Spudich, D. van Dijk, A. Duerr, Y.-C. Ho
The paper uses single-cell profiling to show that immediate ART partially reverses HIV-1 immune dysfunction but does not eliminate persistent HIV-1 RNA+ cells and their clonal expansion.
bioRxiv · Jan 27, 2021 · PreprintImmunology