Author

A. F. Straight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:Xenopus· 3 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

B. T. French· 1 shared J. C. F. Servin· 1 shared M. Kitaoka· 1 shared O. K. Smith· 1 shared R. Heald· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 3 mutual co-author links

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1 shared paperCell Biology

B. T. French

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3 papers

Recent·Most cited

Molecular conflicts disrupting centromere assembly contribute to Xenopus hybrid inviability

M. Kitaoka, O. K. Smith, A. F. Straight, R. Heald

The paper identifies sequence-independent centromere incompatibilities in Xenopus hybrids that disrupt epigenetic pathways required for centromere maintenance, leading to hybrid inviability.

bioRxiv · Mar 6, 2022 · PreprintCell Biology

Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1

J. C. F. Servin, A. F. Straight

This study identifies two mechanisms that inhibit CENP-A assembly in metaphase: HJURP phosphorylation and M18BP1.S competitive binding to CENP-C, and shows their removal allows CENP-A assembly in metaphase.

bioRxiv · Oct 28, 2021 · PreprintCell Biology

CDK phosphorylation of Xenopus laevis M18BP1 promotes its metaphase centromere localization

B. T. French, A. F. Straight

This study shows that CDK phosphorylation of M18BP1 enables its metaphase centromere localization via CENP-C binding, which is critical for proper CENP-A nucleosome assembly.

bioRxiv · Jun 25, 2018Cell Biology