Novel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling Pathway
C. Kundlacz, M. Pourcelot, A. Fablet, R. Amaral Da Silva Moraes, T. Leger, B. Morlet, C. Viarouge, C. Sailleau, M. Turpaud, A. Gorlier, E. Breard, S. Lecollinet, P. A. van Rijn, S. Zientara, D. Vitour, G. Caignard
This paper identifies BTV-NS3 as a virulence factor that activates the MAPK/ERK pathway via interaction with BRAF, promoting viral replication and inflammation.
bioRxiv · Feb 27, 2019Microbiology