Human Dermal Fibroblast Subpopulations and Epithelial Mesenchymal Transition Signals in Hidradenitis Suppurativa Tunnels are Normalized by Spleen Tyrosine Kinase Antagonism in Vivo
A. Flora, R. Jepsen, E. Kozera, J. Woods, G. Cains, M. Razieta, S. Jensen, M. Malone, J. W. Frew
The paper identifies fibroblast subpopulations and EMT signals in HS tissue and shows that Spleen Tyrosine Kinase inhibition reduces inflammation and fibroblast activity.
bioRxiv · Feb 23, 2023Immunology