The evolution of human SIRT1 for multi-specificity is enabled by active-site adaptation
A. Hendler, E. Akiva, M. Sandhu, D. Goldberg, E. Arbely, C. J. Jackson, A. Aharoni
This study investigates the molecular basis and evolution of multi-specificity in SIRT1, finding that active-site adaptations enable the inclusion of p53 as a substrate.
bioRxiv · Jan 12, 2020 · PreprintBiochemistry