CANCER-ASSOCIATED FIBROBLASTS PROMOTE PROSTATE CANCER MALIGNANCY VIA METABOLIC REWIRING AND MITOCHONDRIAL TRANSFER
L. Ippolito, A. Morandi, M. L. Taddei, M. Parri, G. Comito, A. Iscaro, M. R. Raspollini, F. Magherini, E. Rapizzi, J. Masquelier, G. G. Muccioli, P. Sonveaux, P. Chiarugi, E. Giannoni
This study shows that cancer-associated fibroblasts promote prostate cancer malignancy by metabolic reprogramming and mitochondrial transfer through lactate shuttle and cellular bridges.
bioRxiv · Feb 22, 2019Cancer Biology