Characterization of Tigurilysin, a Novel Human CD59-Specific Cholesterol-Dependent Cytolysin, Reveals a Role for Host Specificity in Augmenting Toxin Activity
I. Shahi, S. Dongas, J. K. Ilmain, V. J. Torres, A. J. Ratner
This study characterizes tigurilysin, a novel hCD59-specific CDC, showing it requires both hCD59 and cholesterol for activity and exhibits increased lysis efficiency due to host specificity.
bioRxiv · Jun 21, 2023 · PreprintMicrobiology