Nuclear fascin regulates cancer cell survival
C. D. Lawson, S. Peel, A. Jayo, A. Corrigan, P. Iyer, M. Baxter Dalrymple, R. J. Marsh, S. Cox, I. Van Audenhove, J. Gettemans, M. Parsons
This study shows nuclear fascin supports cancer cell survival by bundling F-actin in the nucleus, enhancing chromatin organization and DNA damage response, and its inhibition reduces invasion and viability.
bioRxiv · Jun 17, 2022Cancer Biology